Known by many names, long COVID (post-acute COVID, chronic COVID) is unfortunately also known to many people. The U.S. Government Accountability Office estimates people suffering from long COVID at 7.7 – 23 million. In late 2021, the World Health Organization defined long COVID as the “constellation of long-term symptoms” suffered by “long-haulers.”
“Every person on average has, like, 16 or 17 symptoms,” says neuroscientist Athena Akrami. These symptoms range from exhaustion and confusion to joint and muscle pain, sleep disturbances, mood changes, hallucinations—even heart attack or stroke. The risk of cardiac problems soars by 72% after even a mild case of COVID, irrespective of age or risk factors. But one of the most distressing aspects is the brain fog that leaves people with memory lapses.
A recent study imaged the brains of more than 400 people, aged 51 to 81, who had contracted COVID-19, compared to those who had not. The data revealed reduction in brain gray matter, primarily in the limbic (emotions and memory) and olfactory (sense of smell) areas, adding up to reduced brain size.
And another study found similarities to brains impacted by neurodegenerative diseases – Alzheimer’s or Parkinson’s. Said study author Nick Reynolds, “What we saw is...ordered assemblies of protein considered ‘molecular hallmarks’ of the early stages of neurodegenerative disease.”
But why these chilling outcomes? Ongoing research reveals several possible causes of the impacts to brains and other body organs.
For one, fragments of virus may linger in your body long after you’re infected. Two recent studies showed that persistent vomiting and diarrhea in people who’d had the virus stemmed from pieces of SARS-CoV-2 hanging out in the gut for months. These “coronavirus ghosts” could explain why long COVID sufferers have problems with multiple body organs.
Another cause could be your immune system going haywire and attacking body tissues. “SARS-CoV-2 is like a nuclear bomb in terms of the immune system,” said infectious disease researcher Steven Deeks. There’s evidence that the virus triggers an auto-immune disorder, in which ”autoantibodies” go rogue and damage organs. The phenomenon is not unprecedented—other viruses such as Epstein-Barr (the virus that causes mono) are also implicated in autoimmune illnesses.
There’s also emerging evidence from children and adults with long COVID that tiny blood clots or damage to blood vessel linings impair blood flow to their lungs.
People have staked their hopes on vaccines to prevent long COVID symptoms even after breakthrough infections. Results are mixed, but a recent study with the biggest sample to date (over 13 million people) shows that vaccination reduces the likelihood of long COVID by only about 15%. And, unfortunately, reports of brain fog and fatigue were similar for vaccinated and unvaccinated study subjects who’d had the virus.
So, the medical community is in an uphill battle to answer urgent questions that will help long COVID sufferers. In the meantime, avoiding the virus has the best outcomes.